Abstract Although engulfment is a hallmark of microglia function, fully validated Small Tray platforms that facilitate high-throughput quantification of this process are lacking.Here, we present FEAST (Flow cytometric Engulfment Assay for Specific Target proteins), which enables interrogation of in vivo engulfment of synaptic material by brain resi
Transfer RNA-derived small RNAs (tsRNAs) are an emerging class of regulatory non-coding RNAs that play important Keyboard Overlay roles in post-transcriptional regulation across a variety of biological processes.Here, we review the recent advances in tsRNA biogenesis and regulatory functions from the perspectives of functional and evolutionary geno
The mechanism of antibody-mediated protection is a major focus of HIV-1 vaccine development and a significant issue in the control of viremia.Virus neutralization, Fc-mediated effector function, or both, are major mechanisms of antibody-mediated protection Clothing against HIV-1, although other mechanisms, such as virus aggregation, are known.The i
The SARS-CoV-2 virus responsible for the COVID-19 global pandemic has exhibited a striking capacity for viral evolution that drives continued evasion from vaccine and infection-induced immune Plush Baby responses.Mutations in the receptor binding domain of the S1 subunit of the spike glycoprotein have led to considerable escape from antibody respon
Allergic diseases have become a primary public health issue in a moderately prosperous society.Colonization of microorganisms early in life appears to be significant in guiding the Agogo Bell regulation of childhood immune system maturation and allergy development.Since the oral cavity is the first position where most foreign antigens meet the immu